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We took a straightforward approach: source pharmaceutical-grade reduced glutathione and dose it at clinically relevant levels

SIDE EFFECTS: TBD

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Lyophilized powder, 99% identity purity

Not expected to present environmental risks

Our findings describe a role for mitochondrial plasticity as a mechanism for acute 5FU tolerance in CRC cells: mitochondrial changes acutely adopted by CRC cells in response to 5FU-based standard-of-care treatment result in increased mitochondrial biogenesis, which provides metabolic support for increased pyrimidine scavenging by UCK2 to resolve nucleotide stress